VegaMC

This package is for version 3.0 of Bioconductor; for the stable, up-to-date release version, see VegaMC.

VegaMC: A Package Implementing a Variational Piecewise Smooth Model for Identification of Driver Chromosomal Imbalances in Cancer

Bioconductor version: 3.0

This package enables the detection of driver chromosomal imbalances including loss of heterozygosity (LOH) from array comparative genomic hybridization (aCGH) data. VegaMC performs a joint segmentation of a dataset and uses a statistical framework to distinguish between driver and passenger mutation. VegaMC has been implemented so that it can be immediately integrated with the output produced by PennCNV tool. In addition, VegaMC produces in output two web pages that allows a rapid navigation between both the detected regions and the altered genes. In the web page that summarizes the altered genes, the link to the respective Ensembl gene web page is reported.

Author: S. Morganella and M. Ceccarelli

Maintainer: Sandro Morganella <sandro at ebi.ac.uk>

Installation

To install this package, start R and enter:

## try http:// if https:// URLs are not supported
source("https://bioconductor.org/biocLite.R")
biocLite("VegaMC")

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("VegaMC")

Details

Package Archives

Follow Installation instructions to use this package in your R session.